ÐÓ°ÉÔ­´´

Skip to Content

Eng Kuan Moo

Assistant Professor

Research Interests:

Research

I am interested in understanding the structure-composition-function relationships and cell-tissue interactions in soft connective tissues. I have worked with biological tissues such as articular cartilage and skeletal muscles. I answer my research questions through carefully designed in vitro, in situ and in vivo experiments and theoretical modelling. By understanding how mechanical forces are transduced through multi-scales to the cells, and how cells interact with the surrounding structural network in their native environment, I hope to apply this knowledge in the field of tissue engineering with the ultimate goal of bio-fabricating a viable and functional tissue substitute for patients who suffer from soft tissue injuries/diseases.

Activities

Journal Articles

  1. Moo, E. K.; Ebrahimi, M.; Sibole, S. C.; Tanska, P.; Korhonen, R. K. The Intrinsic Quality of Proteoglycans, but Not Collagen Fibres, Degrades in Osteoarthritic Cartilage.ÌýActa BiomaterialiaÌý2022,Ìý153, 178–189.Ìý
  2. Sibole, S. C.*,ÌýMoo, E. K.*,ÌýFederico, S.,ÌýHerzog, W. (2022)ÌýThe protective function of directed asymmetry in the pericellular matrix enveloping chondrocytes. Annals of Biomedical Engineering 50 (1): 39 – 55, doi: 10.1007/s10439-021-02900-1
  3. Karjalainen, K., Tanska, P., Sibole, S. C., Mikkonen, S., Herzog, W., Korhonen, R. K.,ÌýMoo, E. K. (2022) Effect of cells on spatial quantification of proteoglycans in articular cartilage. Connective Tissue Research: 1 – 12, doi: 10.1080/03008207.2022.2048827
  4. Moo, E. K.*, Al-Saffar, Y.*, Le, T., Seerattan, R. A., Pingguan-Murphy, B., Korhonen,ÌýR. K.,ÌýHerzog, W. (2021)ÌýDeformation behaviors and mechanical impairments of tissue cracks in immature and mature cartilages.ÌýJournal of Orthopaedic Research, doi: 10.1002/jor.25243
  5. Moo,ÌýE. K., Tanska, P., Federico, S., Al-Saffar, Y., Herzog, W., Korhonen, R. K. (2021) Collagen fibres determine the crack morphology in articular cartilage.ÌýActa BiomaterialiaÌý126: 301–314, doi:10.1016/j.actbio.2021.03.031
  6. Moo, E. K., Leonard, T.R., Herzog, W. (2020) The sarcomere force-length relationship in an intact muscle-tendon unit.ÌýJournal of Experimental Biology, 223 (6): jeb215020, doi: 10.1242/jeb.215020
  7. Moo, E. K.*, Sibole, S. C.*, Han, S. K., Herzog, W. (2017) Three-dimensional micro-scale strain mapping in living biological soft tissues.ÌýActa Biomaterialia,Ìý70: 260-269, doi: 10.1016/j.actbio.2018.01.048
  8. Moo, E. K., Herzog, W.Ìý(2017)ÌýUnfolding of membrane ruffles protects chondrocytes against death.ÌýJournal of Orthopaedic Research, 35(2), 302-310, doi: 10.1002/jor.23260
  9. Moo, E.K., Amrein, M., Epstein, M., Duvall, M., Abu Osman, N.A., Pingguan-Murphy, B., Herzog, W.Ìý(2013). The properties of chondrocyte membrane reservoirs and their role in impact-induced cell death.ÌýBiophysical Journal, 105(7), 1590-1600, doi: 10.1016/j.bpj.2013.08.035
  10. Moo, E. K., Herzog, W., Han, S. K., Abu Osman, N. A., Pingguan-Murphy, B., Federico, S. (2012). Mechanical behaviour of in-situ chondrocytes subjected to different loading rates: a finite element study.ÌýBiomechanics and Modeling in Mechanobiology, 11(7), 983-93, doi: 10.1007/s10237-011-0367-2

* Authors contributed equally to the research work

This site uses cookies to offer you a better browsing experience. Find out more on how we use cookies and how you can change your settings.