Publications
Selected Publications
Antibiotic resistance – Evolution and genomics
Hinz A, Amado A, Kassen R, Bank C, Wong A. 2024. Unpredictability of the fitness effects of antimicrobial resistance mutations across environments in Escherichia coli. Mol Biol Evol 41: msae086.
Ibrahim A, Bradford L, Bult茅 G, Wong A. 2024. Draft Genomes of Meropenem Resistant Pseudomonads from the Cloacae of Turtles in Lake Opinicon, Canada. Microbial Resource Announcements 13.
Cooper AL, Carter C, McLeod H, Sritharan P, Wright M, Koziol AG, Tamber S, Wong A, Carrillo CD, and Blais BW. 2021. Detection of carbapenem-resistance genes in bacteria isolated from wastewater in Ontario. FACETS.
Clarke L, Pelin A, Phan M, Wong A. 2020. The effect of environmental heterogeneity on the fitness of antibiotic resistance mutations in Escherichia coli. Evolutionary Ecology.
Bhatnagar K, Hinz A, Kohlman M, Wong A. 2020. An sRNA screen for reversal of quinolone resistance in Escherichia coli. G3: Genes, Genomes, Genetics 10: 79-88.
Cooper AL, Low AJ, Koziol AG, Thomas MC, Leclair D, Tamber S, Wong A, Blais BW, Carrillo CD. 2020. Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance. Frontiers in Microbiology 11: 549.
Bhatnagar K, Wong A. 2019. The mutational landscape of quinolone resistance in Escherichia coli. PLoS One 14: e0224650.
Wong A. 2019. Hidden risk on the farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance? mSphere 4: e00433-19.
Basra P, Alsaadi A, Bernal-Astrain G, O’Sullivan ML, Hazlett B, Clarke LM, Schoenrock A, Pitre S, Wong A. 2018. Fitness tradeoffs of antibiotic resistance in extra-intestinal pathogenic Escherichia coli. Genome Biology and Evolution 10: 667-679.
Wong A. 2017. Epistatic interactions of antimicrobial resistance mutations. Frontiers in Microbiology 8: 246.
Pathogen Detection and Surveillance
Bradford LM, Yao L, Anastasiadis C, Cooper AL, Deckert A, Reid-Smith R, Lau C, Diarra MS, Carrillo C, Wong A. 2024. Limit of detection of Salmonella ser. Enteritidis using culture-based versus culture-independent diagnostic approaches. Microbiology Spectrum 12: 12.
Bradford LM, Carrillo CD, Wong A. 2024. Managing false positives during detection of pathogen sequences in shotgun metagenomics datasets. BMC Bioinformatics 25: 372.
Cooper A, Low A, Wong A, Tamber S, Blais BW, Carrillo CD. 2024. Modeling the Limits of Detection for Antimicrobial Resistance Genes in Agri-Food Samples: A Comparative Analysis of Bioinformatics Tools. BMC Microbiology 24: 31.
Fralick M, Nott C, Moggridge J, Castellani L, Raudanskis A, Guttman DS, Hinz A, Thampi N, Wong A, Manuel D, McGeer A, Doukhanine E, Mejbel H, Zanichelli V, Burella M, Donaldson S, Wang PW, Kassen R, MacFadden D. 2023. Detection of Covid-19 Outbreaks Using Built Environment Testing for SARS-CoV-2. NEJM Evidence 2.
Hinz A, Xing LY, Doukhanine E, Hug LA, Kassen R, Ormeci B, Kibbee RJ, Wong A, MacFadden D, Nott C. 2022. SARS-CoV-2 Detection from the Built Environment and Wastewater and Its Use for Hospital Surveillance. FACETS.
Policy
Wong A, Hinz A, Mac-Seing M, Carabin H, Zarowsky C. 2021. The role of the environment within the One Health approach: The case of infectious diseases. .
Ruckert A, Farfard P, Hindmarch S, Morris A, Packer C, Patrick D, Weese S, Wilson K, Wong A, and Labont茅 R. 2020. Governing Antimicrobial Resistance: A Narrative Review of Global Governance Mechanisms. Journal of Public Health Policy.
Experimental evolution
Filipow N, Mallon S, Shewaramani S, Kassen R, Wong A. 2024. The Impact of Genetic Background During Laboratory Evolution of Pseudomonas aeruginosa in a Cystic Fibrosis-like Environment. Evolution 78: 566-578.
Wong A and Seguin K. 2015. Effects of genotype on rates of substitution during experimental evolution. Evolution 69:1772-85.
Pathogen comparative genomics
Mattrasingh D, Hinz A, Phillips L, Carroll AC, and Wong A. 2021. Hybrid Nanopore-Illumina assemblies for five extra-intestinal pathogenic Escherichia coli isolates. Microb Resour Announc 10: e01027-20.
Huus KE, Joseph J, Zhang L, Wong A, Aaron SD, Mah T-F, Sad S. 2016. Clinical isolates of Pseudomonas aeruginosa from chronically infected cystic fibrosis patients fail to activate the inflammasome during both stable infection and pulmonary exacerbation. J Immunol 196: 3097-108.
Other
Shukri A, Carroll A, Collins R, Charih F, Wong A, Biggar KK. 2024. Systematic in vitro optimization of antimicrobial peptides against Escherichia coli. JAC Antimicrob Resist 6: dlae096.
Romero J, Islam Md. T, Taylor R, Grayson C, Schoenrock A, Wong A. 2022. High-throughput design of bacterial antisense RNAs using CAREng. Bioinformatics Advances 2: vbac069.
Diaz S, LeBlanc DP, Gagne R, Behan NA, Wong A, Marchetti F, MacFarlane AJ. 2021. Folate Intake Alters Mutation Frequency and Profiles in a Tissue- and Dose-Specific Manner in MutaMouse Male Mice. Journal of Nutrition 151: 800.
Page R, Wong A, Arbuckle TE, MacFarlane AJ. 2019. The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women. American Journal of Clinical Nutrition 110: 401-409.
Burnside D, Schoenrock A, Moteshareie H, Hooshyar M, Samanfar B, Basra P, Hajikarimloo M, Dick K, Barnes B, Kazmirchuk T, Jessulat M, Pitre S, Babu M, Green JR, Wong A, Dehne D, Biggar KK, Golshani A. 2019. In silico engineering of synthetic binding proteins from random amino acid sequences. iScience 11: 375-387.
Sexual selection and seminal fluid proteins (from the distant past)
Wong A. 2014. Covariance between testes size and substitution rates in primates. Molecular Biology and Evolution 31: 1432-1436.
Wong A, Rundle H. 2013. Natural selection on the Drosophila seminal fluid protein Acp62F. Ecology and Evolution 3: 1942-1950.
Wong A. 2010. Testing the effects of mating system variation on rates of molecular evolution in primates. Evolution 64: 2779-85.