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Edward Lai

Professor

• Ph.D. (Florida)
• 230 Steacie Building, �Ӱ�ԭ�� University
• 1125 Colonel By Drive, Ottawa, ON, K1S 5B6
• Email Edward Lai
• 613-520-2600 ext 3835

Research Area: Analytical and bioanalytical chemistry

Specific Topics:

Instrumental analysis of biochemical and environmental samples for public health using capillary electrophoresis, dynamic light scattering, fluorescence spectroscopy, gel permeation chromatography, liquid chromatography, mass spectrometry and 3D microfluidics. New photochemical, electrochemical and optical phenomena are developed into analytical methods for enhanced sensitivity and selectivity:  (a) molecularly imprinted polymers for the selective determination of therapeutic drugs in serum, ochratoxin A in red wine, and estrogenic compounds in wastewater treatment by solid-phase extraction with differential pulsed elution; (b) self-assembled monolayers and electropolymerized thin films for adsorption of toxic metals (Hg²⁺) and mycotoxins; (c) functionalization of colloidal nanoparticles for removal of endocrine disrupting compounds in environmental water and radioactive nuclides (Pu-238, Sr-90, Y-90,) in urine; (d) detection of nanoparticles in environmental water and air samples; (e) microfluidic prints for testing antimicrobial resistance of bacteria (E. coli); (f) DNA binding with inorganic oxide nanomaterial surfaces; (g) interaction of nanoparticles with graphene quantum dots and simulated lung fluid.

Publications:

(132)      Meissam Noroozifar, Zafar Iqbal and Edward P.C. Lai, 2016, “CE-UV Analysis of Biochemically Active Compounds loading onto Chitosan-coated Magnetic Nanoparticles”, Journal of Research Analytica, 2(3), 1-7.

(131)      Audrey Murray, Banu Örmeci and Edward P.C. Lai, 2016, “Use of Sub-micron Sized Resin Particles for Removal of Endocrine Disrupting Compounds and Pharmaceuticals from Water and Wastewater”, Journal of Environmental Science, available online July 25.

(130)      Edward P.C. Lai, Isa Mohammed, Cheryl MacPhee and Alison R. Schwass, 2016, “Surface Plasmon Resonance Biosensor for Immunoassay of Peanut Allergenic Proteins”, Journal of Research Analytica, 2(1), 5-11.

(129)      Edward P.C. Lai, Zafar Iqbal and Tyler J. Avis, 2016, Antimicrobial Agents – Combating Antimicrobial Resistance of Foodborne Microorganisms”, Journal of Food Protection, 79(2), 321-336.

(128)      Audrey Murray, Banu Örmeci and Edward P.C. Lai, 2016, “Removal of Endocrine Disrupting Compounds from Wastewater using Polymer Particles”, Water Science & Technology, 73(1), 176-181.

(127)     Olaitan Edu and Edward P.C. Lai, 2015, “Airborne Silica and Titanium Dioxide Nanoparticles: Collection with Aqueous Surfactant or Chemical Reagent”, Journal of Nanomaterials & Molecular Nanotechnology, 4:2. doi:10.4172/2324-8777.1000162

(126)      Samar Alsudir and Edward P.C. Lai, 2015, “Enhancement of Detection Sensitivity for Colloidal Nanoparticles in Capillary Electrophoresis Analysis”, Journal of Analytical & Bioanalytical Techniques, 6(3), 1000242.

(125)      Yacoob Shaikh, Edward P.C. Lai, Baki Sadi, Chunsheng Li, 2015, “Magnetic Nanoparticles Hybrid Material Synthesis containing Polymeric 18-Crown-6 Ether: Binding and Detection of Radioactive Strontium”, Nanoscience and Technology: Open Concept, 2(1), 1-5.

(124)      Noof A. Alenazi, Jeffrey M. Manthorpe and Edward P.C. Lai, 2015, “Selective Extraction of BPA in Milk Analysis by Capillary Electrophoresis using a Chemically Modified Molecularly Imprinted Polymer”, Food Control, 50, 778–783.

(123)      Zackary Varve, Edward P.C. Lai, Baki Sadi and Chunsheng Li, 2015, “Selective Extraction of ⁹⁰Sr in Urine using 4’4”(5”)Di-tert-butyl Dicyclohexano-18-crown-6 Ether immobilized on Polyacrylamide-coated Magnetic Nanoparticles”, Journal of Radioanalytical and Nuclear Chemistry, 303(1), 1053-1057.

(122)      Noof Alenazi, Edward P.C. Lai and Jeffrey Manthorpe, 2014, “Enhanced Selectivity of Molecularly Imprinted Polymer towards Target Molecule by Esterification of Non-Specific Binding Sites with Diazomethane”, Journal of Molecular Recognition, 27(12), 755-762.

(121)      Edward P.C. Lai, Zafar Iqbal and Sherif Nour, 2014, “Polymerization of Vinylpyrrolidone to form a Neutral Coating on Anionic Nanomaterials in Aqueous Suspension for Rapid Sedimentation”, Coatings, 4(2), 340-355.

(120)      Musharraf Miah, Zafar Iqbal and Edward P.C. Lai, 2014, “A comparative CE-UV binding tests study between polydopamine-coated and polypyrrole-coated magnetic nanoparticles with endocrine disrupting compounds and pharmaceuticals in water”, CLEAN Soil Air Water, 43(2), 173-181.

(119)      Samar Alsudir and Edward P.C. Lai, 2014, “Polymer Coatings for Sensitive Analysis of Colloidal Silica Nanoparticles in Water”, Colloid and Polymer Science, 292, 1289-1296. DOI: 10.1007/s00396-014-3184-1.

(118)      Zafar Iqbal and Edward P.C. Lai, 2013, “Investigation of Polydopamine Growth on Nanomaterials in Water”, Journal of Nanomaterials and Molecular Nanotechnology, 2(6),  doi: 10.4172/2324-8777.1000127.

(117)      Natalie Mesnic, Baki Sadi, Chunsheng Li and Edward Lai, 2013, “Application of Magnetic Nanoparticles for the Extraction of Radium-226 from Water Samples”, Journal of Radioanalytical and Nuclear Chemistry, 298(3), 1501-1509.

(116)      Samar Alsudir and Edward P.C. Lai, 2013, “High Specificity of Molecularly Imprinted Polymer Particles toward Target Compound in Competitive Environmental Binding”, European Chemical Bulletin, 2(3), 112-118.

(115)      Xinlong Xia, Edward P.C. Lai and Banu Ormeci, 2013, “Duo-Molecularly Imprinted Polymer-Coated Magnetic Particles for Class-Selective Removal of Endocrine Disrupting Compounds from Aqueous Environment”, Environmental Science & Pollution Research, 20(5), 3331-3339.

(114)      Mark Pereira and Edward P.C. Lai, 2012, “Interaction of Estrogen-functionalized Quantum Dots with Anti-estrogen Antibodies via Capillary Electrophoresis”, Micro & Nanosystems, 4(4), 320-325.

(113)      Zafar Iqbal, Edward P.C. Lai and Tyler J. Avis, 2012, “Antimicrobial Effect of Polydopamine Coating on Escherichia coli”, Journal of Materials Chemistry (I.F. = 5.9), 22(40), 21608-21612.

(112)      Musharraf Miah, Zafar Iqbal and Edward P.C. Lai, 2012, “Rapid In-Capillary CE-UV Binding Tests of Endocrine Disrupting Compounds and Pharmaceuticals with Polypyrrole-coated Magnetic Nanoparticles”, Analytical Methods, 4(9), 2866-2878.

(111)      Xinlong Xia, Edward P.C. Lai and Banu Ormeci, 2012, “Ultrasonication Assisted Synthesis of MIP-Encapsulated Magnetic Nanoparticles for Rapid and Selective Removal of 17β-Estradiol from Aqueous Environment”, Polymer Engineering & Science, 52(8), 1775–1783.

(110)      Zack Varve, Edward P.C. Lai, Chunsheng Li, Baki B. Sadi, and Gary H. Kramer, 2012, “Polymer-coated magnetic nanoparticles for rapid bioassay of ⁹⁰Sr in human urine samples”, Journal of Radioanalytical and Nuclear Chemistry, 292, 1411-1415.

(109)      Samar Alsudir, Zafar Iqbal and Edward P.C. Lai, 2012, “Rapid CE-UV Binding Tests for Selective Recognition of Bisphenol A by Molecularly Imprinted Polymer Particles”, Electrophoresis, 33(8), 1255-1262.

(108)      Amy Hrdina, Edward Lai, Chunsheng Li, Baki Sadi and Gary H. Kramer, 2012, “Synthesis of Crown Ether Modified Cation Exchange Polymer Particles for ⁹⁰Sr Urinalysis”, Reactive and Functional Polymers, 72, 295-302.

(107)      Zafar Iqbal, Edward P.C. Lai and Tyler J. Avis, 2012, “Development of polymer-modified magnetic nanoparticles and quantum dots for Escherichia coli binding test”, Microchimica Acta (I.F. = 3.0), 176(1), 193-200.

(106)      Edward P. C. Lai, Negar Bahraini, Chunsheng Li, Baki B. Sadi, and Gary H. Kramer, 2012, “Cd²⁺, Cu²⁺, Pb²⁺, Sr²⁺ and Y³⁺ Binding Characteristics of 17b-Estradiol Molecularly Imprinted Polymer Particles (Impregnated with Dicyclohexano-18-Crown-6) for Urine Bioassay”, Journal of Applied Polymer Science, 123(1), 12-19.

(105)      Min Liu, Edward P.C. Lai and Yu Yang, 2012, “Removal of 17β-Estradiol by Nylon Filter Membrane: Adsorption Kinetics and Thermodynamics”, International Journal of Research and Reviews in Applied Sciences, 11(1), 67-73.

(104)      Giao Do, Edward P.C. Lai and Mohammad Hassanzadeh-Khayyat, 2011, “Degradation of Diclofenac by Acid Treatment for Water Purification using Molecularly Imprinted Polymer Particles”, Journal of Advanced Pharmaceutical Research, 2(4), 150-156.

(103)      Min Liu, Edward P.C. Lai and Yu Yang, 2011, “Removal of 17β-Estradiol by Nylon Filter Membrane: Adsorption Mechanism, pH Effect and Temperature Influence”, Proceedings, World Congress on Engineering and Technology (CET 2011, Shanghai, China, October 28-30.

(102)      Baki B. Sadi, Chunsheng Li, Gary H. Kramer, Cassandra L. Johnson, Queenie Ko and Edward P.C. Lai, 2011, “Rapid Determination of ²²⁶Ra in Drinking Water Samples Using Dispersive Liquid-Liquid Microextraction Coupled with Liquid Scintillation Counting”, Journal of Radioanalytical and Nuclear Chemistry, 290(2), 415-425.

(101)      Mohammad Hassanzadeh-Khayyat, Edward P.C. Lai, Kerim Kollu and Banu Ormeci, 2011, “Degradation of Diclofenac in Molecularly Imprinted Polymer Submicron Particles by UV Light Irradiation and HCl Acid Treatment”, Journal of Water Resource and Protection, 3(9), 643-654.

(100)      Audrey Murray, Banu Ormeci and Edward Lai, 2011, “Removal of 17b-Estradiol and Chlorination By-products from Water and Wastewater using Non-Imprinted Polymer Particles” Water Science and Technology, 64(6), 1291-1297.

(99)         Yu Yang and Edward P.C. Lai, 2011, “Optimization of Molecularly Imprinted Polymer Method for Rapid Screening of 17b-Estradiol in Water by Fluorescence Quenching,” International Journal of Analytical Chemistry, Article ID 214747, 8 pages.  doi:10.1155/2011/214747.

(98)        Zafar Iqbal, Samar Alsudir, Musharraf Miah and Edward P.C. Lai, 2011, “Rapid CE-UV Binding Tests of Environmentally Hazardous Compounds with Polymer-modified Magnetic Nanoparticles”, Electrophoresis, 32, 1-7.

(97)        Badruz Zaman, Toya Nath Baral, Zygmunt J. Jakubek, Jianbing Zhang, Edward Lai, Dennis Whitfield and Kui Yu, 2011, “Single-Domain Antibody Bioconjugated Near-IR Quantum Dots for Targeted Cellular Imaging of Pancreatic Cancer”, Journal of Nanoscience and Nanotechnology, 11, 1–7.

(96)        Amy Hrdina, Edward P.C. Lai, Chunsheng Li, Baki Sadi, and Gary Kramer, 2011, “Rapid ⁹⁰Sr Bioassay using Magnetic Cation Exchange Polymer Suspension”, Health Physics Journal, 101(2), 187-195.

(95)        Negar Bahraini, Edward P.C. Lai, Chunsheng Li, Baki B. Sadi and Gary H. Kramer, 2011, “Molecularly Imprinted Polymers for ⁹⁰Sr Bioassay”, Health Physics Journal, 101(2), 128-135.

(94)        Audrey Murray, Banu Ormeci and Edward Lai, 2010, “Evaluation of Non-Imprinted Polymer Nanoparticles for Removal of Endocrine Disrupting Compounds from Surface Water and Wastewater”, Proceedings of WEFTEC 2010, Water Environment Federation, New Orleans, Louisiana, October 2-6, 2010.

(93)       Jorn C.C. Yu and Edward P.C. Lai, 2010, “Molecularly Imprinted Polymers for Ochratoxin A Extraction and Analysis”, Toxin, 2(6), 1536-1553.

(92)        Baki Sadi, Chunsheng Li, Negar Bahraini, Edward Lai and Gary H. Kramer, 2010, “Selectivity of ⁹⁰Sr Urine Bioassay Technique over ²⁴¹Am, ^238/239Pu, ²¹⁰Po, ¹³⁷Cs and ⁶⁰Co”, Radiation Protection Dosimetry, 141(2), 205-209.

(91)        Yiyan Li and Edward P.C. Lai, 2010, “Extraction of 17b-Estradiol in Water using Non-imprinted Polymer Submicron Particles in Syringe Filters”, Journal of Environmental Science, 22(11) 1820–1825.

(90)        Yu Yang and Edward P.C. Lai, 2010, “An Investigation of Porous Structure in Molecularly Imprinted Polymer for Sensor Development:  Non-linear Fluorescence Quenching of 17β-Estradiol bound inside MIP Submicron Particles by Sodium Nitrite and Methacrylamide”, Journal of Photochemistry and Photobiology A: Chemistry,  213, 123-128.

(89)        Zack DeMaleki, Edward P.C. Lai and Ewa Dabek-Zlotorzynska, 2010, “Capillary Electrophoresis Characterization of Molecularly Imprinted Polymer Particles in Fast Binding with 17β-Estradiol”, Journal of Separation Science, 116 (3), 2796-2803.

(88)        Amy Hrdina, Edward P.C. Lai, Chunsheng Li, Baki Sadi, and Gary Kramer, 2010, “A Comparative Study of Magnetic Transferability of Superparamgnetic Nanoparticles”, Journal of Magnetism and Magnetic Materials, 322, 2622-2627.

(87)        Baki B. Sadi, Chunsheng Li, Sara Jodayree, Edward P.C. Lai, Vera Kochermin and Gary H. Kramer, 2010, “A Rapid Bioassay Method for the Determination of ⁹⁰Sr in Human Urine Sample”, Radiation Protection Dosimetry.  140(1), 41-48.

(86)        Randy Jackson, Ilona Petrickovics, Edward P.C. Lai  and Jorn C.C. Yu, 2010, “Molecularly Imprinted Polymer Stir Bar Sorption Extraction and Electrospray Ionization Tandem Mass Spectrometry for Determination of 2-Aminothiazoline-4-Carboxylic Acid in Forensic Urine Analysis”, Analytical Methods, 2, 552-557.

(85)        Edward P.C. Lai, Zack DeMaleki and Shuyi Wu, 2010, “Characterization of Molecularly-Imprinted and Non-Imprinted Polymer Submicron Particles Specifically Tailored for Removal of Trace 17β-Estradiol in Water Treatment”, Journal of Applied Polymer Science, 116 (3), 1499-1508. (84)        Yu Yang, Edward P.C. Lai and Min Liu, 2010, “Spectroscopic Analysis of Poly (Methacrylic Acid-co-Ethylene Glycol Dimethacrylate) Submicron Particles by Fluorescence Emission and Light Scattering upon Binding with 17β-Estradiol in Water Treatment”, Open Colloid Science Journal, 3(8), 1-8.

(83)        Chunsheng Li, K. Benkhedda, Zack Varve, Vera Kochemin, Baki B. Sadi, Edward P.C. Lai and Gary H. Kramer, 2009, “Fast Methods for ²³⁹Pu Faecal Bioassay”, Journal of Analytical Atomic Spectrometry, 24, 1429–1433.

(82)        Chunsheng Li, Baki B. Sadi, Gerry Moodie, Joseph N. Daka, Edward P.C. Lai, Gary H. Kramer, 2009, “Field Deployable Technique for ⁹⁰Sr Emergency Bioassay”, Radiation Protection Dosimetry, 136(2), 82-86.

(81)        Mark Pereira and Edward P.C. Lai, 2008, “Capillary Electrophoresis for the Characterization of Quantum Dots after Non-selective or Selective Bioconjugation with Antibodies for Immunoassay”, Journal of Nanobiotechnology, 6(1):10.  doi: 10.1186/1477-3155-6-10

(80)        Yun Wei, Long Qiu, Craig Owen and Edward P.C. Lai, 2007, “Encapsulation of Quantum Dots and Carbon Nanotubes with Polypyrrole in a Syringe Needle for Automated Molecularly Imprinted Solid Phase Pre-concentration of Ochratoxin A in Red Wine Analysis”, Sensing and Instrumentation for Food Quality and Safety, 1, 133-141.

(79)        Yun Wei, Longhui Qiu, Jorn C.C. Yu and Edward P.C. Lai, 2007, “Molecularly Imprinted Solid Phase Extraction in a Syringe Needle packed with Polypyrrole-encapsulated Carbon Nanotubes for Determination of Ochratoxin A in Red Wine”, Food Science and Technology International, 13, 375-380.

(78)        Jorn C.C. Yu, Amy Hrdina, Christina Mancini, and Edward P.C. Lai, 2007, “Molecularly Imprinted Polypyrrole Encapsulated Carbon Nanotubes in Stainless Steel Frit for Micro Solid Phase Extraction of Estrogenic Compounds”, Journal of Nanoscience and Nanotechnology, 7(9), 3095-3103.

(77)        Mark Pereira, Edward P.C. Lai and Bryan Hollebone, 2007, “Characterization of Quantum Dots Using Capillary Zone Electrophoresis”, Electrophoresis, 28, 2874-2881.

(76)        Jorn C.C. Yu and Edward P.C. Lai, 2007, “Determination of Ochratoxin A in Red Wines by Multiple Pulsed Elutions from Molecularly Imprinted Polypyrrole”, Food Chemistry, 105, 301-310.

(75)        Ting Lu, Edward P.C. Lai and Jorn C.C. Yu, 2006, “Analysis for Flavonoids in Bee Pollens by Capillary Electrophoresis”, Food Science (ISSN 1002-6630), 27(12), 582-587.

(74)        Ting Lu, Jorn C.C. Yu, Yisu Li, Erika Revesz and Edward P.C. Lai, 2006, “Rapid Analysis for Flavonoids in Propolis by Capillary Electrophoresis”, Food Science (ISSN 1002-6630), 27(8), 208-213.

(73)        Edward P.C. Lai and Sherry Y. Feng, 2006, “Solid Phase Extraction – Non-aqueous Capillary Electrophoresis for Rapid Determination of Metformin in Human Plasma”, Journal of Chromatography B, 843, 94-99.

(72)        Jorn C.C. Yu and Edward P.C. Lai, 2006. “Molecularly Imprinted Polypyrrole Modified Carbon Nanotubes on Stainless Steel Frit for Selective Micro Solid Phase Pre-concentration of Ochratoxin A”, Reactive & Functional Polymers, 66, 702-711.

(71)        Jorn C.C. Yu, Svetla Krushkova, Edward P.C. Lai and Ewa Dabek-Zlotorzynska, 2005, “Molecularly Imprinted Polypyrrole Modified Stainless Steel Frits for Selective Solid Phase Pre-concentration of Ochratoxin A”, Analytical and Bioanalytical Chemistry, 382, 1534-1540.