Publications from Independent Career:
36. Benjamin B. Warnes, Jasmine Chihabi, Jeffrey M. Manthorpe*
“Unveiling Readily Ionized and Robust Anionic Species: A Gateway to Enhanced Ionization Efficiency in ESI-MS Analysis”
Journal of the American Society for Mass Spectrometry, 2025, 36, 524-533. or
35. Christian A. Rosales, Noah A. Lepinsky, Wondewassen Gebeyehu, Karl V. Wasslen, Fraser Colquhoun, Benjamin B. Warnes, Jasmine Chihabi, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“Improved LC-MS Detection of Opioids, Amphetamines, and Psychedelics Using TrEnDi”
Journal of the American Society for Mass Spectrometry, 2025, 36, 514-523. or
34. Volodymyr Semeniuchenko, Sepideh Sharif, Neha Rana, Nalin Chandrasoma, Wilfried M. Braje, R. Tom Baker, Jeffrey M. Manthorpe, William J. Pietro, Michael G. Organ*
“Experimental Evidence for Zerovalent Pd(NHC) as a Competent Catalyst in C鈥揘 Cross-Coupling (NHC = DiMeIHept^Cl)
Journal of the American Chemical Society, 2024, 146, 29224-29236.
33. Joshua A. Roberts, Angela S. Radnoff, Aleksandra Bushueva, Jocelyn A. Menard, Karl V. Wasslen, Meaghan Harley, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“Mobile Phase Contaminants Affect Neutral Lipid Analysis in LC-MS-based Lipidomics Studies”
Journal of the American Society for Mass Spectrometry, 2024, 35, 3095-3106. or
32. Samuel W. J. Shields, Carlos R. Canez, Christian A. Rosales, Joshua A. Roberts, Hilary Bourgaize, Peter J. Pallister, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“Optimized 13C-TrEnDi Enhances the Sensitivity of Plasmenyl Ether Glycerophospholipids and Demonstrates Compatibility with Other Derivatization Strategies”
Journal of the American Society for Mass Spectrometry, 2024, 35, 972-981. or
31. Christian A. Rosales, Krysten L. Sheedy, Karl V. Wasslen, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“Trimethylation Enhancement Using Diazomethane (TrEnDi) Enables Enhanced Detection of Glufosinate and 3-(Methylphosphinico)propionic Acid from Complex Canola Samples”
Journal of the American Society for Mass Spectrometry, 2024, 35, 140-150. or
30. Joshua A. Roberts, Christian A. Rosales, Karl V. Wasslen, Angela S. Radnoff, Elena Godbout, Jean-Simon Diallo, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“An In Silico Database for Automated Feature Identification of High-Resolution Tandem Mass Spectrometry 13C Trimethylation Enhancement Using Diazomethane (13C-TrEnDi)-Modified Lipid Data”
Journal of the American Society for Mass Spectrometry, 2023, 34, 2722-2730. or
29. Christian A. Rosales, Samuel W. J. Shields, Chelsey Aulenback, Elezi Gazmend, Karl V. Wasslen, Peter Pallister, Kym Faull, Jeffrey M. Manthorpe*, Jeffrey C. Smith*
“Improved chromatography and MS-based detection of glyphosate and aminomethylphosphonic acid using iTrEnDi”
Journal of the American Society for Mass Spectrometry, 2023, 34, 948-957.
28. Volodymyr Semeniuchenko, Sepideh Sharif, Jonathan Day, Nalin Chandrasoma, William J. Pietro, Jeffrey M. Manthorpe, Wilfried M. Braje, Michael G. Organ*
“(DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination”
Journal of Organic Chemistry, 2021, 86, 10343-10359.
27. Mathieu A. Morin, Debasis Mallik, Wenyao Zhang, William Pietro, Jeffrey M. Manthorpe, Michael G. Organ*
鈥淥btaining Kinetics from Continuous Processes: Sampling Multiple Time Point Concurrently With a Single Valve Rotation
颁丑别尘颈蝉迟谤测鈥拟别迟丑辞诲蝉 (Open Access), 2021, 1, 131.
26. Monica A. Gill, Samuel W. J. Shields, Jeffrey M. Manthorpe*
鈥淥rigin of Protonation Side Products in Pd-Catalyzed Decarboxylative Allylation Reactions: Evidence for In Situ Modification of Triphenylphosphine Ligand鈥�
ChemRxiv, Feb 2021
25. Samuel W. J. Shields, Christian A. Rosales, Joshua A. Roberts, Peter Pallister, Karl V. Wasslen, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
鈥渋TrEnDi: In Situ Trimethylation Enhancement Using Diazomethane: Improved and Expanded Glycerophospholipid and Sphingolipid Analyses via a Microscale Autonomous Derivatization Platform鈥�
Analytical Chemistry, 2021, 93, 1084-1091.
24. Elissia T. Franklin, Samuel W. J. Shields, Jeffrey M. Manthorpe, Jeffrey C. Smith, Yu Xia, and Scott A. McLuckey*
鈥淐oupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization鈥�
Journal of the American Society for Mass Spectrometry, 2020, 31, 938-945.
23. Monica A. Gill and Jeffrey M. Manthorpe
鈥淒evelopment of Palladium-Catalyzed Decarboxylative Allylation of Electron-Deficient Sulfones and Identification of Unusual Side Products鈥�
Journal of Organic Chemistry, 2019, 84, 6028-6039.
22. Samuel W. J. Shields, Peter H. Buist, and Jeffrey M. Manthorpe*
鈥淎symmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange鈥�
SynOpen (Open Access),听2018, 2, 168-175.
21. Stella K. Betancourt,听Carlos R. Canez, Samuel W. J. Shields, Jeffrey M. Manthorpe, Jeffrey C. Smith, and Scott A. McLuckey*
“Trimethylation Enhancement using 13C-Diazomethane (13C-TrEnDi): Gas-Phase Charge Inversion of Modified Phospholipid Cations for Enhanced Structural Characterization”
Analytical Chemistry 2017, 89, 9452-9458.
20. Carlos R. Canez, Samuel W. J. Shields, Magdalena Bugno, Karl V. Wasseln, Hillary P. Weinert, William G. Willmore, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
鈥淭rimethylation Enhancement using 13C-Diazomethane (13C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine and Phosphatidylserine Lipids Derived from Complex Biological Samples鈥�
Analytical Chemistry 2016, 88, 6996-7004.
19. Noof A. Alenazi, Jeffrey M. Manthorpe, Edward P. C. Lai*
鈥淪electivity Enhancement in Molecularly Imprinted Polymers for Chemical Sensing of Bisphenol A鈥�
Sensors聽(Open Access)聽2016, 16, 1697 (12 pages). (Invited contribution to thematic issue on Molecular Imprinting for Transducers and Applications).
18. Noof A. Alenazi, Jeffrey M. Manthorpe, and Edward P. C. Lai*
鈥淪elective Extraction of BPA in Milk Analysis by Capillary Electrophoresis using a Chemically Modified Molecularly Imprinted Polymer鈥�
Food Control 2015, 50, 778-783.
17. Karl V. Wasslen, Carlos R. Canez, Hyunmin Lee, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
鈥淭rimethylation Enhancement using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge鈥�
Analytical Chemistry 2014, 86, 9523-9532.
16. Samuel W. J. Shields and Jeffrey M. Manthorpe*
鈥淓fficient, Scalable, and Economical Preparation of tris(Deuterium)- and 13C-Labelled N-Methyl-N-Nitroso-p-Toluenesulfonamide (Diazald庐) and their Conversion to Labelled Diazomethane鈥�
Journal of Labelled Compounds and Radiopharmaceuticals 2014, 57, 674-679.
15. Noof A. Alenazi, Edward P. C. Lai, and Jeffrey M. Manthorpe*
鈥淓nhanced Selectivity of a Molecularly Imprinted Polymer toward the Target Molecule via Esterification of Non-Specific Binding Sites with Diazomethane鈥�
Journal of Molecular Recognition 2014, 27, 755-762.
14. Karl V. Wasslen, Le Hoa Tan, Jeffrey M. Manthorpe*, and Jeffrey C. Smith*
鈥淭rimethylation Enhancement using Diazomethane (TrEnDi): Rapid On-Column Quaternization of Peptide Amino Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge鈥�
Analytical Chemistry 2014, 86, 3291-3299.
13. Jeffrey M. Manthorpe*, Han Il Kong, John W. Palko, and Monica A. Gill
鈥淩eduction of Sulfur鈥揅arbon Bonds and of Other Heteroatoms Bonded to Tetrahedral Carbon鈥�
Comprehensive Organic Synthesis, 2nd Edition; Molander, G. A., Knochel, P., Eds; Elsevier: Oxford, 2014; Vol. 8, pp 1031-1085.
12. John W. Palko, Peter H. Buist, and Jeffrey M. Manthorpe*
鈥淎 Flexible and Modular Stereoselective Synthesis of (9R,10S)-Dihydrosterculic Acid鈥�
Tetrahedron: Asymmetry 2013, 24, 165-168.
11. Han Il Kong, Monica A. Gill, Amy H. Hrdina, Jennifer E. Crichton, and Jeffrey M. Manthorpe*
鈥淩eactivity of 伪-Trifluoromethanesulfonyl Esters, Amides and Ketones: Decarboxylative Allylation, Methylation, and Enol Formation鈥�
Journal of Fluorine Chemistry, 2013, 153, 151-168.
10. Monica A. Gill and Jeffrey M. Manthorpe*
鈥淢ild, Rapid, and Inexpensive Microwave-Assisted Synthesis of Allylic and Propargylic Esters鈥�
Synthetic Communications 2013, 43, 1460-1468.
9. Han Il Kong, Jennifer E. Crichton, and Jeffrey M. Manthorpe*
鈥淪tereoselective Synthesis of Ambiphilic Alkenes via Regioselective Methylation of 伪-Trifluoromethansulfonyl Carbonyl Compounds with Trimethylsilyldiazomethane鈥�
Tetrahedron Letters 2011, 52, 3714-3717.
Publications from聽Postdoctoral, Graduate and Undergraduate Studies:
8. Alex M. Szpilman, Damiano M. Cereghetti, Jeffrey M. Manthorpe, Nicholas R. Wurtz, and Erick M. Carreira
鈥淪ynthesis and Biophysical Studies on 35-Deoxy Amphotericin B Methyl Ester鈥�
Chemistry, A European Journal 2009, 15, 7117-7128.
7. Alex M. Szpilman, Jeffrey M. Manthorpe, and Erick M. Carreira
鈥淪ynthesis and Biological Studies of 35-Deoxy Amphotericin B Methyl Ester鈥�
Angewandte Chemie International Edition 2008, 47,听4339-4342.
6. Alex M. Szpilman, Damiano M. Cereghetti, Nicholas R. Wurtz, Jeffrey M. Manthorpe, and Erick M. Carreira
鈥淪ynthesis of 35-Deoxy Amphotericin B Methyl Ester: A Strategy for Molecular Editing鈥�
Angewandte Chemie International Edition 2008, 47, 4335-4338.
5. Az茅lie Arpin, Jeffrey M. Manthorpe, and James L. Gleason
鈥淎 Practical Chiral Bicyclic Thioglycolate Lactam Auxiliary for Stereoselective Quaternary Carbon Formation鈥�
Organic Letters 2006, 8, 1359-1362.
4. Jeffrey M. Manthorpe, Alex M. Szpilman, and Erick M. Carreira
鈥淎 Scalable Synthesis of a Mycosamine Donor. Overcoming Difficult Reactivity in Allose Systems鈥�
Synthesis 2005, 3380-3388.
3. Jeffrey M. Manthorpe and James L. Gleason
“Asymmetric Synthesis of Quaternary Carbon Centers. Alkylation of 伪,伪-Disubstituted Enolates Generated by Reduction of Bicyclic Thioglycolate Lactams”
Angewandte Chemie International Edition 2002, 41, 2338-2341.
2. Gordon L. Lange, Craig C. Humber, and Jeffrey M. Manthorpe
“[2+2] Photoadditions with Chiral 2,5-Cyclohexadienone Synthons”
Tetrahedron: Asymmetry 2002, 13, 1355-1362.
1. Jeffrey M. Manthorpe and James L. Gleason
“Stereoselective Generation of E- and Z- Disubstituted Amide Enolates.聽 Reductive Enolate Formation from Bicyclic Thioglycolate Lactams”
Journal of the American Chemical Society 2001, 123, 2091-2092.