{"id":232,"date":"2020-05-26T19:06:33","date_gmt":"2020-05-26T19:06:33","guid":{"rendered":"https:\/\/carleton.ca\/neuroscience\/?post_type=cu_people&#038;p=232"},"modified":"2026-06-25T09:48:08","modified_gmt":"2026-06-25T13:48:08","slug":"michael-hildebrand","status":"publish","type":"cu_people","link":"https:\/\/carleton.ca\/neuroscience\/people\/michael-hildebrand\/","title":{"rendered":"Michael Hildebrand"},"content":{"rendered":"<header class=\"mb-6 cu-pageheader cu-component-updated md:mb-12\">\n    <h1 class=\"cu-prose-first-last font-semibold !mt-2 mb-4 md:mb-6 text-3xl md:text-4xl lg:text-5xl lg:leading-[3.5rem] relative after:absolute after:h-px after:bottom-0 pb-5 after:w-10 after:bg-cu-red after:left-px\">\n                    \n             \n                \n            <\/h1>\n\n    \n    <\/header>\n\n\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Mike Hildebrand completed his PhD in neurophysiology at UBC, followed by an industrial R&amp;D fellowship at NeuroMed Pharmaceuticals in Vancouver. After this, Mike completed an academic postdoctoral fellowship at Sick Kids Hospital. Mike is now leading a translational pain research program as a Professor in the Department of Neuroscience at ÐÓ°ÉÔ­´´ University and as an Affiliate Investigator at The Ottawa Hospital. His dynamic team of undergraduate, graduate, and postdoctoral researchers are studying mechanisms and potential treatment targets for pain using a combination of animal models and pioneering human spinal cord preclinical assays. Mike also serves as Associate Vice-Provost (Graduate Student Affairs) in the <a href=\"https:\/\/carleton.ca\/provost\/profile\/michael-hildebrand\/\">Office of Graduate Studies<\/a>. He&#8217;s also a runner and loves candy!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Eligible to supervise <\/strong>at the undergraduate and graduate level.<\/p>\n\n\n\n<h3 id=\"past-courses-taught\" class=\"wp-block-heading\">Past Courses Taught:<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NEUR 3206: Sensory and Motor Neuroscience<\/li>\n\n\n\n<li>NEUR 4200: Seminar on Current Advances in Neuroscience<\/li>\n<\/ul>\n\n\n\n<h3 id=\"scholarly-work-research-interests\" class=\"wp-block-heading\">Scholarly Work &amp; Research Interests:<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The Hildebrand Lab investigates spinal mechanisms of pain processing. They use a combination of molecular, pharmacological, electrophysiological, and behavioural approaches to identify the molecular pathways that regulate pain sensation in both acute and chronic pain states. The goals of the lab include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Exploring spinal networks in both rodent and human tissue models of pain bridge the translational divide between basic science research and the unmet clinical needs of chronic pain patients<\/li>\n\n\n\n<li>Identifying new molecular targets and potential treatment approaches for managing chronic pain<\/li>\n<\/ul>\n\n\n\n<h3 id=\"selected-publications\" class=\"wp-block-heading\">Selected Publications:<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Griffiths, K.<sup>*<\/sup>, Armstrong, J.<sup>*<\/sup>, Martin, N., Murray-Lawson, C., Oneil, E., David, L.S.,\u00a0 Temi, S., Dedek, A., Parnell, J., Rudyk, C., Krajewski, J.L., McDermott, J.S., Levine, A.J., Li, B., Tsai, E.C., <strong>Hildebrand, M.E.<\/strong> (2026) Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development. Journal of Neuroscience. <a href=\"https:\/\/doi.org\/10.1101\/2025.10.22.683915\">https:\/\/doi.org\/10.1101\/2025.10.22.683915<\/a>. <em><sup>*<\/sup>Both authors contributed equally to this work. \u00a0<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dedek, A., Gambeta, E., Shriraam, R., Topcu, E., McDermott, J.S., Krajewski, J.L., Tsai, E.C., <strong>Hildebrand, M.E.<\/strong> (2026) Processing and sectioning of organ donor spinal cord tissue for electrophysiology on acute human spinal cord slices. Brain Communications. doi:<a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcag157\">https:\/\/doi.org\/10.1093\/braincomms\/fcag157<\/a> https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13179502\/<em>\u00a0<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dedek, A., Alles, S.R.A, <strong>Hildebrand, M.E.<\/strong> (2026) Electrophysiological analysis of human pain-processing cells and circuits. <em>Anesthesia &amp; Analgesia<\/em>. <a href=\"https:\/\/journals.lww.com\/anesthesia-analgesia\/citation\/9900\/electrophysiological_analysis_of_human.1840.aspx\">https:\/\/journals.lww.com\/anesthesia-analgesia\/citation\/9900\/electrophysiological_analysis_of_human.1840.aspx<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bellavance, J., David, L.S., <strong>Hildebrand, M.E.<\/strong> (2024) An open-source tool for investigation of differential RNA expression between spinal cord cells of male and female mice. Journal of Neuroscience Research. 102(12): e70008. https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.70008<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dedek, A., Topcu, E., Dedek, C., McDermott, J.S., Krajewski, J.L., Tsai, E.C., <strong>Hildebrand, M.E. (<\/strong>2024) Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain-processing neurons across sex in rats and humans. The Journal of Physiology. 602(20): 5309-5327. https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP285521<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Parnell, J.,Martin, N., Dedek, A., Rudyk, C., Landrigan, J., Bellevance, J., Vanderloo, S., Tsai, E.C., <strong>Hildebrand, M.E.<\/strong> (2023) Cannabinoid CB1 receptor expression and localization in the dorsal horn of male and female human and rat spinal cord. Canadian Journal of Pain. 7(2): 1-16. https:\/\/www.tandfonline.com\/doi\/10.1080\/24740527.2023.2264895?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dedek, A., Xu, J., Lorenzo, L.E., Kandegedara, C., Godin, A.G., Glavina, G., Landrigan, J., Lombroso, P.J., Tsai, E.C., De Koninck, Y., <strong>Hildebrand, M.E.<\/strong> (2022) Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain. Brain. 145(3): 1124-1138. https:\/\/academic.oup.com\/brain\/article\/145\/3\/1124\/6551129?login=true<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Click <a href=\"https:\/\/scholar.google.com\/citations?user=bR_JmTYAAAAJ&amp;hl=en&amp;oi=ao\">here<\/a> to see all publications. <\/p>\n","protected":false},"author":2,"featured_media":6450,"template":"","meta":{"_acf_changed":false,"cu_people_first_name":"Michael","cu_people_last_name":"Hildebrand","cu_people_initials":"","footnotes":"","_links_to":"","_links_to_target":""},"cu_people_type":[30],"cu_people_expertise":[61],"class_list":["post-232","cu_people","type-cu_people","status-publish","has-post-thumbnail","hentry","cu_people_type-faculty","cu_people_expertise-pain-signals"],"acf":{"cu_people_job_title":"Professor","cu_people_degree":"PhD (University of British Columbia)","cu_building":"HS","cu_people_office_num":"6310","cu_people_pronoun":"","cu_people_designation":"","cu_people_email":"Mike.Hildebrand@carleton.ca","cu_people_phone":"","cu_people_phone_ext":"","cu_people_linkedin":"","cu_people_bluesky":"","cu_people_twitter":"https:\/\/twitter.com\/mikehildebrand7","cu_people_instagram":"","cu_people_facebook":"","cu_people_website":"https:\/\/hildebrandpainlab.com\/","cu_people_orcid":""},"_links":{"self":[{"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people\/232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people"}],"about":[{"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/types\/cu_people"}],"author":[{"embeddable":true,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":4,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people\/232\/revisions"}],"predecessor-version":[{"id":10008,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people\/232\/revisions\/10008"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/media\/6450"}],"wp:attachment":[{"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/media?parent=232"}],"wp:term":[{"taxonomy":"cu_people_type","embeddable":true,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people_type?post=232"},{"taxonomy":"cu_people_expertise","embeddable":true,"href":"https:\/\/carleton.ca\/neuroscience\/wp-json\/wp\/v2\/cu_people_expertise?post=232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}