News Archives - MuBEST Laboratory

Research on cartilage and cartilage cells published in Connective Tissue Research and Journal of Biomechanics!

EngKuanMoo — Sat, 29 Jun 2024 02:01:13 +0000

We are pleased to announce that our research on cartilage and cartilage cells are recently published in and . For the work in Connective Tissue Research, we used multi-modal, histochemical imaging techniques to investigate the effects of obesity and joint injury on the structure and composition of articular cartilage. For the study published in the Journal of Biomechanics, we used multi-photon laser scanning microscopy and found that cartilage cells perceived and responded differently to dynamic compared to static mechanical cues. Importantly, we show that the cells were able to quickly adapt volumetrically and morphologically to cyclical mechanical loads. These studies improve our understanding of how cartilage and cells respond to different biomechanical and biochemical perturbations, which may be used to establish the mechanism of the painful joint diseases such as osteoarthritis.

Feel free to check out the articles through the hyperlinks above for more details. If you do not have access to the article, please email the PI for a private copy.

Imaging-based method to assess functional quality of articular cartilage

EngKuanMoo — Sat, 20 Jan 2024 16:42:23 +0000

It is our pleasure to announce that our collaborative work with the University of Calgary on using multi-photon laser microscopy to assess functional quality of human cartilage is now published in the Annals of Biomedical Engineering.

Check for the article. If you do not have access to the article, please email the PI for a private copy.

Article alert! On the sarcomere non-uniformity

EngKuanMoo — Mon, 15 Jan 2024 15:27:41 +0000

We are pleased to announce that our work on investigating the origin of sarcomere non-uniformity at the myofibril level is now published in the Frontiers in Physiology.

Check for the article. If you do not have access to the article, please email the PI for a private copy.

New article on hydrogel reinforcement by MEW mesh published in JMBBM

EngKuanMoo — Wed, 14 Jun 2023 15:09:08 +0000

We are pleased to announce that our work on investigating the reinforcement of hydrogels by melt-electrowritten (MEW) mesh is now published in the Journal of the Mechanical Behavior of Biomedical Materials.

Check for the article. If you do not have access to the article, please email the PI for a private copy.

Research funding

EngKuanMoo — Fri, 09 Jun 2023 15:12:14 +0000

We are pleased to announce that the lab will be supported by NSERC Discovery grant for the next few years to investigate the factors influencing the development of tissue adhesion between native and engineered tissues!

Summer students 2023

EngKuanMoo — Fri, 09 Jun 2023 15:02:53 +0000

This summer we are welcoming seven researchers to the group!

Ankush Deol, Mikhail Chizhov, Kangkan Sarkar, and Yazan Zeidat join as undergraduate research assistants.

Abdelaziz Atahran, Mehdi Mazari, and Riphael Check join us from France for this summer.

They will work on various research including constructing a novel bioreactor for tracking tissue adhesion development, a low-cost melt-electrowriting printer, and various topics regarding biomechanics of cartilage tissue and cells.

Check here for their personal profile.

Again, welcome to the group. We hope you have a good time researching this summer!

MuBEST lab is founded

NADINEBASIL — Fri, 20 Jan 2023 17:13:53 +0000

It is of great pleasure that we announce the establishment of the Multi-scale Biomechanics and Engineering of Soft Tissues (MuBEST) laboratory at �Ӱ�ԭ�� University. In this research group, we conduct fundamental research at multiple length scales spanning from tissue to molecule to gain insights into the mechanisms related to the onset and repair of soft tissues. Soft tissues of interest are articular cartilage and skeletal muscles. Please visit here to get more information!